Illustration of the effects of acetaminophen on glutathione, Download Scientific Diagram N acetylcysteine (NAC) Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Electrochemical evidences in oxidation of acetaminophen in the presence of glutathione and N acetylcysteine Chemical Communications (RSC Publishing) Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective Full article: The development and hepatotoxicity of acetaminophen: reviewing over a century of progress