Vulvovaginal melanocytic lesions: a review Diagnostic Histopathology Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Melanocytic lesions of the conjunctiva: an up to date review Diagnostic Histopathology Labial melanotic macule pathology image Labial melanotic macule pathology image ORAL MELANOTIC MACULE (OMM) (Also called focal melanosis labial melanotic macule) A benign, localized, flat pigmented lesion of the oral mucosa Caused by a focal increase in melanin production