The Liver: Inflammation, Oxidative Stress, and Glutathione Synthesis IMMA Immunity Matters Glutathione synthetase Wikipedia GCLC, the rate limiting enzyme in glutathione synthesis, promotes liver Download Scientific Diagram What is glutathione? Know as the most important antioxidant in the body, glutathione is an essential antioxidant manufactured in all cells, but primarily in the liver. It is essential because it Glutathione Synthesis in Normal Liver and in Yoshida AH 130 Hepatoma Hepatic Glutathione Synthesis: The Liver's Antioxidant Powerhouse Glutathione (GSH) is the most abundant intracellular antioxidantand the liver is its primary production site. Through a tightly regulated, ATP dependent pathway, hepatocytes