Inflammasome activation as a key driver of acetaminophen induced hepatotoxicity: Mechanisms and emerging therapeutics EurekAlert! Oxidative stress mediates end organ damage in a novel model of acetaminophen toxicity in Drosophila Scientific Reports Illustration of the effects of acetaminophen on glutathione, Download Scientific Diagram Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. The Hidden Impact of Acetaminophen Well Rooted PGC 1 Induces Susceptibility To Acetaminophen Driven Acute Liver Failure Scientific Reports