How Many Vape Puffs Is One Cigarette? ARR Brand Nicotine use among young people is evolving. New research shows more youth are using multiple nicotine products at the same timemost commonly cigarettes and e cigarettes, with a growing rise in combining vapes 1 vape vs. 1 pack of cigarettes A single vape cartridge can have the nicotine equivalent of 600 cigarettes. How Many Cigarettes Equals One Vape Device? How Many Puffs of a 20MG Vape Is Equal to a Cigarette?