Can You Donate Blood If You Smoke Weed? Elevate Holistics Can You Donate Plasma If You Smoke Weed? Get Facts Here! The Sanctuary Yes, you can donate blood if you smoke or consume cannabis. The recipient of the blood will not get high, another common MYTH. All donors go through the same health Smoking (or vaping) doesn't affect your ability to donate blood. Help us bust this myth by sharing our post. FAQs Shepeard Blood Can you donate blood if you smoke?